Cell biologists identify infection mechanism of adenoviruses

March 20, 2017

"In this ferret study, we used doses of antigen at 1/50th of the standard commercial dose, and then combined the antigen with our nanoemulsion adjuvant prior to vaccination," said Ali I. Fattom, Ph.D., Senior Vice President of Vaccine Research and Development, NanoBio. "Despite the low antigen dose, the ferrets vaccinated responded with robust systemic titers against influenza. These data reflect the significant antigen-sparing properties of our nanoemulsion adjuvant platform. In addition, the cross-protection observed indicates our adjuvant can enhance cross-reactive antibodies, which could play an important role in developing a future universal vaccine for influenza."

James R. Baker, Jr., MD, NanoBio's Founder & CEO added, "We have selected influenza as our lead vaccine candidate as a model or proof of concept for our nanoemulsion adjuvant platform. The research described in this publication represents a critical step for NanoBio, and provided the impetus for proceeding directly to Phase 1 studies. As we stand today, we are currently conducting a Phase 1b study in influenza to optimize our results in humans. In parallel, we are aggressively pursuing development programs for nanoemulsion-adjuvanted vaccines for RSV and UTI, based on the promise we have seen with our influenza vaccine."

Source: NanoBio

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