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Data from RGN-259 study published in Archives of Ophthalmology

March 08, 2017

The Company has previously performed anti-HIV nanoviricides testing in vivo at KARD Scientific, Beverly, MA. In these studies, several nanoviricide drug candidates were shown to have equal effectiveness in terms of multiple parameters to a clinical anti-HIV HAART three-drug cocktail. The HAART cocktail drugs were administered at a much greater total dosage (4,100 mg/kg of HAART) than the nanoviricides (only 150mg/kg of the nanoviricides). This study evaluated several parameters including the reduction of HIV viral load, improvement in CD4+/CD8+ double-positive human T cells, and HIV particle count inside human T cells in the transplant, among others. The best nanoviricide drug candidate was greater than 25X (2,500%) superior to the HAART drug cocktail based on the amount of drug that produced comparable or superior effect. If these results are indicative of clinical response in humans, the Company believes that HIVCide?„?, its lead drug candidate against HIV, may constitute a "functional cure" for HIV/AIDS, either by itself, or in combination with existing therapies.

"We are very interested to find out how our prior results compare to the standardized studies in Dr. Stoddart's lab," said Anil R. Diwan, PhD, President of the Company.

SOURCE NanoViricides, Inc.