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New technique allows production of medically useful amounts of endoderm cells from human PSCs

April 27, 2017

This technique allowed the team to detect cell inefficiencies and develop a new understanding of the underlying cell biology during the differentiation of PSCs. This allowed the team to increase effective cell production 35 fold.

"Our results showed significant increases in the amount of endoderm cells generated," said Ungrin. "This new concept allows us to scale up the production of useful cells, while ensuring PSC survival and effective differentiation."

Overcoming this bottleneck in research will also help future stem cell researchers navigate the often long and challenging route from laboratory testing to clinical use, and accelerate the time from biomedical advance to beneficial therapy, often referred to as the bench-to-bedside process.

"Most research in this field focuses on the purity of generated cell populations; the efficiency of differentiation goes unreported," concluded Dr Ungrin. "However our research provides an important template for future studies of pluripotent stem cells, particularly where cells will need to be produced in quantity for medical or industrial uses."

Source: Wiley-Blackwell